Introducing Core BOLIC V2: Unleash Your Full Potential with Nature's Power
In the pursuit of peak physical performance, rapid recovery, and overall well-being, we present to you Core BOLIC V2—an innovative fusion of heavily studied ingredients meticulously crafted to elevate your capabilities. At its core are three remarkable components: PeptiStrong™, Maral Root Extract, and Camellia sinensis Extract, (fortified by the bioenhancing prowess of BioPerine®. Together, these elements unlock a world of possibilities that extend beyond the ordinary.
Fava Bean (Vicia faba) Hydrolysate (as PeptiStrong™)
PeptiStrong™ is an ingredient derived from fava beans that contains extremely beneficial natural compounds called bioactive peptides. Other sources of naturally occurring bioactive peptides are collagen, insulin, and glutathione, all of which have crucially beneficial properties. These peptides have undergone patent protection and extensive research, including both pre-clinical and clinical studies. The studies have shown positive effects on gene expression and the secretion of tumor necrosis factor alpha (TNF-a). In vitro experiments using murine skeletal muscle cells and human macrophages have validated the ability of the peptides within PeptiStrong™ to increase muscle protein synthesis and reduce TNF-a secretion. The study also assessed the bioavailability and stability of the peptides, which proved to be resistant to digestion, displayed good intestinal barrier transport, and remained stable in plasma.
In an in vivo study using a murine model of muscle atrophy, PeptiStrong™ treatment for 18 days resulted in a significant attenuation of muscle loss and increased expression of muscle fibers. The treatment also upregulated protein-synthesis-related genes in muscle tissue. Other protein hydrolysates of fava bean and food-derived hydrolysates did not exhibit the same level of efficacy in vitro. Thus, PeptiStrong™ demonstrated efficacy in attenuating muscle atrophy through various mechanisms, including inflammation reduction and muscle protein synthesis.
A clinical study compared the effects of PeptiStrong™ and milk protein supplementation on muscle mass and strength loss during limb immobilization. The study involved 30 young men subjected to one-legged knee immobilization followed by recovery. PeptiStrong™ supplementation performed similarly to milk protein in modulating muscle size loss during immobilization and regain during remobilization. Notably, higher muscle protein synthesis rates were observed during remobilization in the PeptiStrong™ group.
Another study with 30 healthy male subjects investigated the effects of PeptiStrong™ supplementation on strength recovery and fatigue. The subjects were divided into groups receiving either a placebo or 2.4 grams of PeptiStrong™ daily. Delayed onset muscle soreness (DOMS) was induced using resistance exercise, and the subjects' strength recovery and fatigue were measured over three days. PeptiStrong™ supplementation significantly improved strength recovery, reduced fatigue, and positively influenced markers associated with muscle homeostasis. Myostatin expression was also found to be significantly reduced, indicating an anabolic response following intense exercise.
Maral Root Extract (Rhaponticum carthamoides) (10:1)
Maral Root Extract, derived from the plant Rhaponticum carthamoides, is a natural ingredient highly regarded for its adaptogenic properties and numerous health benefits. This herb has a rich history in traditional medicine and is known for its ability to enhance physical and mental performance, support stress resilience, boost energy levels, promote vitality, improve athletic performance, and aid in post-exercise recovery. One crucial aspect of athletic performance is the ability to maintain a high capacity throughout the event and be able to then recover efficiently. Maral Root Extract has shown potential in addressing both of these aspects. Let's first examine how this herb can enhance measures of athletic performance.
When it comes to increasing endurance, two key factors play a significant role: oxygen and adenosine triphosphate (ATP). Oxygen is essential in breaking down carbohydrates, fats, and proteins and converting them into ATP, the primary energy source for the body. Maral Root Extract has been found to increase ATP production, which can allow individuals to exercise for longer periods and delay the onset of fatigue.
Furthermore, studies suggest that Maral Root Extract supplementation may promote greater muscle protein synthesis. While the exact mechanisms of 20-hydroxyecdysone (a plant ecdysteroid) on muscle protein synthesis are not fully elucidated, it appears to involve a rapid increase in calcium in the cell (cytosol) causing activation of Akt/PI3K signaling. This signaling promotes the metabolism, proliferation, cell survival, growth, and angiogenesis of cells. Along with these increases in muscle protein synthesis, Maral Root Extract has also been shown to aid in muscle recovery and improve muscular strength, enabling individuals to generate more power during workouts.
Moreover, the active compounds present in Maral Root Extract, such as ecdysteroids and additional flavonoids, exhibit potential anti-inflammatory and antioxidant effects through their adaptogenic properties. These properties can help the body adapt to physical and mental stressors and can further contribute to improved muscle recovery, reduced exercise-induced muscle damage, and faster bounce back after intense training sessions.
Additionally, Maral Root Extract has been found to influence hormone levels, particularly testosterone and cortisol. It can help maintain a healthy testosterone-cortisol ratio, which is beneficial for muscle growth and recovery. Achieving hormonal balance can contribute to better exercise performance and body composition.
Camellia sinensis Extract (Bean) (std. to 90% Epicatechin)
Epicatechin is a plant-based phytochemical, or flavanol, that is found in trace amounts in foods and liquids such as dark chocolate and green tea. Its physiological benefits have been studied for years and have resulted in promising results in relation to:
These proposed benefits listed above and the compelling research surrounding them has led epicatechin to be involved in innovations where muscle growth and improved performance are the goal.
How does epicatechin work? Glad you asked. The proposed mechanism of action of epicatechin is through the inhibition of myostatin, which is a type of protein called a myokine that in essence acts as a regulating molecule released by muscles. Increased levels of myostatin have been linked to limiting the level of muscle growth. To combat an increased concentration of myostatin, epicatechin can work to increase another protein called follistatin which the body can then use to control metabolism, promote muscle growth, and boost fertility. Increased myostatin has been linked to the clinically obese and inactive as well as individuals who have some degree of insulin resistance. Studies have shown that aerobic activities, strength training, and some modifications to diet can, to a degree, decrease myostatin levels in muscle. When it comes to epicatechins ability to increase follistatin levels and further inhibit myostatin concentrations as few studies have been conducted for its efficacy.
One study conducted on males showed that just 170mg of epicatechin per day was able to increase follistatin by about 50% and decrease myostatin by about 17%, which also coincided with an increase in strength of about 7%.
Looking at epicatechins nitric oxide boosting benefits, one animal study showed that nitric oxide and endurance was able to be increased even in the absence of exercise. This can aid in nutrient absorption and improved heart and muscle health outside of the gym but in the gym, it can also result in greater blood flow to muscles and stimulate a better pump in response to training.
The literature that has been presented on epicatechin in in vivo studies on muscle growth potential and improved overall health is promising and when combined with the other ingredients in this product, the body can be set up for the most beneficial environment for muscle growth, strength increases, and increases in performance.
Bioperine® (Piper nigrum) (Fruit) (std. to 95% Piperine):
BioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by.
BioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.
Several studies looking at the impact of BioPerine® on nutrient absorption and several plant compounds have been done. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks on BioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.