The following is a mini crash course in how insulin works in the body:
All dietary carbohydrates are broken down into the monomer glucose in the small intestine, which then is absorbed into the bloodstream. Once in the blood, glucose signals the pancreas to secrete insulin. Insulin will then bind to the insulin receptor (IR), where it triggers a series of reactions that ultimately
leads to uptake of glucose and amino acids into the cell, glycogen synthesis, increased muscle protein synthesis, and glucose disposal (glycolysis), usually through the insulin receptor substrate/phosphoinositide 3-kinase (IRS/PI3K) pathway. GLUT4, a transporter needed to allow glucose to enter the cell, is translocated to the cell membrane via activation of the IR, and IRS pathway. Different pathways lead to different actions elicited by insulin, and herein lies how one can maximize the use of endogenous insulin to increase lean body mass or lose body fat.
Bitter Melon Extract(standardized to 10% bitters):Known as “vegetable insulin,” bitter melon is used to treat diabetes in many parts of the world, and in some places it’s the only form of treatment. Bitter melon contains a variety of hypoglycemic herbs such as triterpenes, anthroquinones, and glucosinolates. The 3 most profound ones are charantin, polypeptide-p, and vicine. Studies have shown extracts from bitter melon to stimulate insulin release, increase skeletal muscle glucose uptake and utilization, suppress gluconeogenic enzymes, and preserve and regenerate beta cells(the cells that release insulin in the pancreas). There is even research on these compounds activating AMPK and PPARx, both of which help regulate energy expenditure in the body.
Banaba leaf Extract(standardized to 25% tannins):Lagerstromemin speciosa, commonly known as banaba leaf, contains many compounds that can naturally help with blood sugar control. Most people assume it’s the work of corsolic acid, for which most banaba supps are standardized. However, it’s actually the gallotannins that are responsible the most for insulin memetic function. Specifically, Penta- O-galloyl-glucopyranose(PGG) was determined to have the strongest effect of the group. PGG was shown to significantly increase glucose transport into cells, both in vitro and in vivo. It also was shown to have an anti-adipogenic(inhibit fat cell production) effect, which many other glucose disposal agents do not possess(remember, insulin is adipogenic).Lagerstromeminwas also identified to activate the insulin
receptor(IR), one mechanism for lowering blood glucose. One of the other major mechanisms of action for banaba leaf is increasing expression and activation of GLUT-4, the transporter protein that allows glucose to be absorbed into cells. Interestingly, removing tannins from banaba extract eliminated all glucose transport activity(GLUT4), which also suggests that the tannins, not corsolic acid is responsible for the anti-diabetic effects. Another study showed that Lagerstromeminwas about 54% as strong as insulin for glucose transport activity, which is pretty remarkable.
Alpha Lipoic Acid(yielding 150mg of R-ALA):Alpha Lipoic acid is a mitochondrial fatty acid with really interesting properties. It's been extensively studied for a multitude of benefits, but perhaps the most applicable are its use as an anti-oxidant and a tool to manage blood glucose levels and increase insulin sensitivity. ALA has been shown to reduce general biomarkers for oxidation, inflammatory cytosine and lipid peroxidation(generation of free radicals that can damage your cells). In a meta-analysis, ALA was shown to have a remarkable effect on blood glucose levels. It can increase expression of GLUT-4, the transport protein than shuttles glucose into your cells. It can also decrease the activity of phosphotyrosine phosphatase 1B(PTP1B), a negative regulator insulin response, as well as potentiating the insulin receptor substrate-1. All of these mechanisms can result in more carbohydrates going into your muscles instead of being stored as fat. R-ALA is one of the most important ingredients in GDA and works synergistically with the other ingredients to reduce blood glucose levels and increase glucose uptake in muscle cells.
Gymnema Sylvestre Extract(standardized to 75% Gymnemic acids):Gymnema sylvestre(GS) is a natural antidiabetic herb that has been used to treat blood sugar ailments for centuries. GS contains triterpenoid saponins called gymnemic acids that stimulate the release of insulin from the pancreas, as well as increase glucose uptake in cells. GS extract has also been shown to lower LDL and vLDL(bad cholesterol), as well as increase HDL(good cholesterol). In addition,gymnema sylvestreextract has been shown to regenerate islet cells in your pancreas, which allows your body to regulate healthy insulin secretion and function.
Super Berberine®(Berberine-Cyclodextrin complex):Berberine is one of the only supplements that has human data that shows efficacy on par with pharmaceuticals. It's main properties are activation of 5' adenosine monophosphate-activated protein kinase(AMPK), which leads to fatty acid oxidation, inhibition of cholesterol synthesis and lipogenesis, increases in muscle glucose uptake and insulin secretion(amongst other things). Focusing on muscle glucose uptake and insulin secretion, berberine was shown to very effective as a glucose disposal agent in serval studies.Berberine may increase glucose-stimulated insulin secretion and inhibit α-glucosidase activities, as well as promoting glucose uptake in cells. It works by increasing phosphorylation of the insulin receptor, insulin receptor substrate- 1, and protein kinase B. Berberine also inhibits the enzyme PTP1B, an enzyme that down regulates the insulin pathway which can also lead to insulin resistance. The main problem with Berberine is it has terrible bioavailability. Super Berberine is Berberine encased in beta-cyclodextrin, which has been shown to increase solubility by over double of free berberine in a simulated gastric environment. Super Berberine also contains sodium caprate, a fatty acid that increases diffusion of berberine through the epithelial cells in the intestine.
Cinnulin PF®:Cinnulin PF® is a patented version of a 20:1 extract of Cinnamomum burmannithat contains high levels of water soluble double-linked procyanidin type-A polymers of flavanoids. Research shows that these polymers can increase autophosphorlyation of the insulin receptor-β, insulin receptor substrate-1, and phosphatidylinositol 3-kinase, all of which activates the receptors and increases the ability for insulin to bind, as well as inhibits the enzyme phosphotyrosine phosphatase(PTP1B), which dephosphorlyates(inactivates) the insulin receptor.
By potentiating the insulin receptor, your body can use less insulin to absorb the same amount of glucose, thus increasing your insulin sensitivity. The polymers in Cinnulin PF® hav ealso been shown to increase GLUT-4 expression, the transporter molecule that brings glucose into cells.
Chromium(III) polynicotinate:Although it has been known that chromium(III) (Cr) has positive effects on blood glucose control, the mechanism by which it does this has not been fully elucidated until
recently. It was shown that insulin binds to the insulin receptor(IR) and then Cr binds in a second binding pocket, which increases IR activity anywhere from 3.5-8 fold, which has a downstream effect on multiple insulin-dependent pathways. Essentially, Chromium allows your body to use insulin more effectively due toits 2 binding sites on the IR. The polyniconinate chelate of Chromium has been found to be more bioavailable than other versions.
Chemix® GDAis a premium insulin memetic formula that combines 7 of the most well-studied and effective ingredients for maximizing the power of the anabolic hormone insulin! These carefully selected ingredients work with different mechanisms to allow your body to increase lean body mass by shuttling more glucose and amino acids into your cells, priming the perfect anabolic environment for growth. GDA can also help lower blood sugar levels, as well as increase insulin sensitivity, which may aid in fat loss!
- The Guerrilla Chemist
speciosa. Evidence-Based Complementary and Alternative Medicine. 2007;4(4):401-7.2. Al‐Romaiyan, A., et al. "A novel Gymnema sylvestre extract stimulates insulin secretion from
human islets in vivo and in vitro."Phytotherapy Research24.9 (2010): 1370-1376.
diabetes."Nutrition reviews58.3 (2000): 67-72.
after oral administration of alpha-lipoic acid."HORMONES-ATHENS-5.4 (2006): 251.
medicinal potency."Asian Pacific Journal of Tropical Disease3.2 (2013): 93-102.
Metabolism57.5 (2008): 712-717.
of Alternative and Complementary Medicine13.9 (2007): 977-983.
isolated diaphragm."Journal of Biological Chemistry237.1 (1962): 118-122.
berberinehydrochloride, a P-glycoprotein substrate. International Journal of Biological Macromolecules. 2013 Aug;59:363–71.
hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. Mol Cell Endocrinol. 2012 Nov 5;363(1-2):122–30.
features of the metabolic syndrome in pre-diabetic men and women."Journal of the International Society of Sports Nutrition3.2 (2006): 45. 14. Rachh, P. R., et al. "Antihyperlipidemic activity of Gymenma sylvestre R. Br. leaf extract on rats fed
with high cholesterol diet." Int J Pharmacol6.2 (2010): 138-141.